Cluster Preface: Challenges of Proline-Based Aminocatalysis

Abstract

During the last eleven years, aminocatalysis, the catalysis of carbonyl transformations via iminium ion and enamine intermediates has become a highly successful and general approach to asymmetric synthesis. There are now several dozens of different ­reaction types with hundreds of variants that are mediated by primary and secondary amine catalysts, of which proline continues to be a privileged motif. This Cluster highlights recent attempts towards solving some of the remaining challenges in the area.

proline - aminocatalysis - enamine catalysis - iminium ion catalysis

References and Notes

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