Download PDF
Synlett 2011(5): 730-731  
DOI: 10.1055/s-0030-1259685
SPOTLIGHT
© Georg Thieme Verlag Stuttgart ˙ New York

Sodium Chlorite

Marcelle Lima de Ferreira*
Instituto de Química, Universidade Federal do Rio de Janeiro, Avenida Athos da Silveira Ramos, 149 Bloco A - 7˚ Andar CEP 21941-909, Cidade Universitária, Rio de Janeiro, RJ, Brazil
e-Mail: marcellelf@gmail.com;
Further Information

Publication History

Publication Date:
25 February 2011 (online)

   Permissions and Reprints All articles of this category

Introduction

Sodium chlorite (NaClO2) is a highly efficient bleaching agent and oxidative disinfectant, widely applied in bleaching of textile, fiber, pulp and paper. In addition, this substance is employed to whiten sugar, starch, grease, ointment and wax. [¹]

In organic synthesis, NaClO2 is an inexpensive and versatile reagent, which has been explored for preparations of carboxylic acids from aldehydes [²] or primary alcohols [³] , amides from imines, [4] enones from allylic and benzylic substrates, [5] epoxides from olefins [6] and γ-hydroxybutenolides from furans. [7] Moreover, this reagent has also been employed in the oxidative deprotection of 1,3-dithiane groups, [8] as oxidant and hydroxyl ion pump in osmium-catalyzed asymmetric dihydroxilation [9] as well as in the ­iodination of aromatic and heterocyclic compounds. [¹0]