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Synthesis 2011(11): 1733-1740  
DOI: 10.1055/s-0030-1260047
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Facile Synthesis of 6H-[1,3,5]Triazino[2,1-b]quinazolin-6-ones

Shaun Abbott, Josée Cloutier, Karine Houde, Christopher Penney, Boulos Zacharie*
ProMetic BioSciences Inc., 500 boulevard Cartier Ouest, Bureau 150, Laval, QC, H7V 5B7, Canada
Fax: +1(450)7811403; e-Mail: b.zacharie@prometic.com;
Further Information

Publication History

Received 7 January 2011
Publication Date:
13 May 2011 (online)

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Abstract

Triazinoquinazolinone derivatives are synthesized by cyclization of aminobenzamide-substituted triazine compounds in the presence of a proton source such as trifluoroacetic acid or hydrochloric acid. The reaction is mild, general, and gives high yield (>90%) of the cyclized product. This procedure allows, for the first time, access to triazinoquinazolinone compounds bearing different functionalities on the benzene and triazine moieties that are not available by other routes.

Key words

amides - heterocycles - cyclization - carboxylic acids - esters

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