Isatoic Anhydride

Introduction

The abundance of heterocyclic motifs in bio-active natural products challenges many researchers to acquire such heterocyclic compounds in the laboratory level. The progress of green chemistry in the synthetic process favors the tandem reactions over the multistep synthesis. Isatoic anhydride (1) is a fascinating molecule with a broad spectrum in the synthesis of pharmaceuticals and natural products by tandem reactions. It is commercially available and can be synthesized by different approaches (Scheme  [¹] ). [¹]

Scheme 1  Synthesis of isatoic anhydride (1)

References

• 1 Deligeorgiev T. Vasilev A. Vaquero JJ. Alvarez-Builla J. Ultrason. Sonochem.  2007,  14:  497 
• 2a Zhang ZH. Lu HY. Yang SH. Gao JW. J. Comb. Chem.  2010,  12:  643 
• 2b Chen JX. Su WK. Wu HY. Liu MC. Jin C. Green Chem.  2007,  9:  972 
• 3 Mohammadi AA. Dabiri M. Qaraat H. Tetrahedron  2009,  65:  3804 
• 4 Yoshino Y. Kurahashi T. Matsubara S. J. Am. Chem. Soc.  2009,  131:  7494 
• 5 Dabiri M. Baghbanzadeh M. Delbari AS. J. Comb. Chem.  2008,  10:  700 
• 6 Bakavoli M. Davoodnia A. Shahnaee R. Chin. Chem. Lett.  2008,  19:  12 
• 7 Gajare AS. Shaikh NS. Jnaneshwara GK. Deshpande VH. Ravindranathan T. Bedekar AV. J. Chem. Soc., Perkin Trans. 1  2000,  999 
• 8 Swamy SJ. Suresh K. Someshwar P. Nagaraju D. Synth. Commun.  2004,  34:  1847 
• 9 Bijukumar G. Maloyesh B. Sampat SS. Bhirud SB. Rajendra A. Synth. Commun.  2008,  38:  1718 
• 10 Pettersson B. Hasimbegovic V. Bergman J. Tetrahedron Lett.  2010,  51:  238