Abstract
Diethanolamine-complexed heterocyclic boronic acids (DABO boronates)
are air-stable reagents that can be used directly in Suzuki-Miyaura
reactions in the presence of water or a protic co-solvent. Interestingly,
heterocyclic DABO boronates can be stored for extended periods of
time at room temperature with no noticeable degradation, unlike
their boronic acid counterparts. Heterocyclic DABO boronates constitute
an operationally simple and efficient alternative to other boronic
acid derivatives as coupling partners in palladium-catalyzed cross-coupling
reactions under standard Suzuki-Miyaura conditions.
Key words
Suzuki-Miyaura reaction - cross-coupling - palladium catalysis - heterocyclic boronate - aryl
boronate
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