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Synlett 2011(16): 2307-2310
DOI: 10.1055/s-0030-1261219
DOI: 10.1055/s-0030-1261219
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Facile Synthesis of Highly Substituted Iminocyclopentenes: A Novel Isocyanide-Based Three-Component Condensation Reaction
Further Information
Received
16 May 2011
Publication Date:
08 September 2011 (online)
Publication History
Publication Date:
08 September 2011 (online)
Abstract
The reaction of alkoxymethylenemalononitrile with dialkyl acetylenedicarboxylates (DAAD) and cyclohexylisocyanide results in a three-component condensation reaction in which the alkoxymethylenemalononitrile group acts as a dipolarophile, producing highly functionalized iminocyclopentenes under mild conditions in high yields.
Key words
alkoxymethylenemalononitrile - dialkyl acetylenedicarboxylates - isocyanides - iminocyclopentenes
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