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Synlett 2011(16): 2384-2386  
DOI: 10.1055/s-0030-1261236
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Microwave-Enhanced Reaction of Thioacids with Azides in Aqueous Medium

Pallavi Sharma, Adam D. Moorhouse, John E. Moses*
School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
Fax: +44(115)9513564; e-Mail: john.moses@nottingham.ac.uk;
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Publikationsverlauf

Received 20 July 2011
Publikationsdatum:
13. September 2011 (online)

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Abstract

An efficient entry to aromatic amides using microwave irradiation in aqueous medium is described. Starting from substituted anilines, in situ formation of the corresponding aromatic azide is followed by their immediate reaction with a thioacid to yield amides in excellent yield. This improved protocol significantly reduces the reaction time thus increasing the overall efficiency of this useful transformation.

Key words

aromatic amides - azides - thio acids - microwave - one pot

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