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Synlett 2011(16): 2384-2386
DOI: 10.1055/s-0030-1261236
DOI: 10.1055/s-0030-1261236
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Microwave-Enhanced Reaction of Thioacids with Azides in Aqueous Medium
Further Information
Received
20 July 2011
Publication Date:
13 September 2011 (online)
Publication History
Publication Date:
13 September 2011 (online)
Abstract
An efficient entry to aromatic amides using microwave irradiation in aqueous medium is described. Starting from substituted anilines, in situ formation of the corresponding aromatic azide is followed by their immediate reaction with a thioacid to yield amides in excellent yield. This improved protocol significantly reduces the reaction time thus increasing the overall efficiency of this useful transformation.
Key words
aromatic amides - azides - thio acids - microwave - one pot
- Supporting Information for this article is available online:
- Supporting Information
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