RSS-Feed abonnieren
DOI: 10.1055/s-0030-1263074
Nutrition in Head and Neck Cancer Patients
Publikationsverlauf
Publikationsdatum:
20. August 2010 (online)
ABSTRACT
Anorexia and cachexia frequently complicate the late stages of malignancy and can be a prominent feature of early disease. The resulting weight loss significantly affects the morbidity and mortality of the cancer patient. A fundamental understanding of nutrition and the pathophysiology of cancer cachexia will aid in diligent treatment decisions to achieve optimal results. The pathophysiology of cancer cachexia is discussed, together with methods of nutritional assessment, nutritional requirements, and postoperative nutritional support. The advantages and disadvantages of the various modes of parenteral and enteral feeding are presented, together with information about enteral feeding in the home.
KEYWORDS
Cachexia - malnutrition - nutritional support - percutaneous endoscopic gastrostomy
REFERENCES
- 1 Lees J. Incidence of weight loss in head and neck cancer patients on commencing radiotherapy treatment at a regional oncology centre. Eur J Cancer Care (Engl). 1999; 8 133-136
- 2 Nitenberg G, Raynard B. Nutritional support of the cancer patient: issues and dilemmas. Crit Rev Oncol Hematol. 2000; 34 137-168
- 3 Tchekmedyian N S, Zahyna D, Halpert C, Heber D. Assessment and maintenance of nutrition in older cancer patients. Oncology (Williston Park). 1992; 6(2, Suppl) 105-111
- 4 Arbeit J M, Lees D E, Corsey R, Brennan M F. Resting energy expenditure in controls and cancer patients with localized and diffuse disease. Ann Surg. 1984; 199 292-298
- 5 Axelrod L, Costa G. Contribution of fat loss to weight loss in cancer. Nutr Cancer. 1980; 2 81-83
- 6 Oliff A, Defeo-Jones D, Boyer M et al.. Tumors secreting human TNF/cachectin induce cachexia in mice. Cell. 1987; 50 555-563
- 7 Strassmann G, Fong M, Freter C E, Windsor S, D'Alessandro F, Nordan R P. Suramin interferes with interleukin-6 receptor binding in vitro and inhibits colon-26-mediated experimental cancer cachexia in vivo. J Clin Invest. 1993; 92 2152-2159
- 8 Argilés J M, Moore-Carrasco R, Fuster G, Busquets S, López-Soriano F J. Cancer cachexia: the molecular mechanisms. Int J Biochem Cell Biol. 2003; 35 405-409
- 9 Goodwin Jr W J, Torres J. The value of the prognostic nutritional index in the management of patients with advanced carcinoma of the head and neck. Head Neck Surg. 1984; 6 932-937
- 10 Gardine R L, Kokal W A, Beatty J D, Riihimaki D U, Wagman L D, Terz J J. Predicting the need for prolonged enteral supplementation in the patient with head and neck cancer. Am J Surg. 1988; 156 63-65
- 11 Magné N, Marcy P Y, Foa C et al.. Comparison between nasogastric tube feeding and percutaneous fluoroscopic gastrostomy in advanced head and neck cancer patients. Eur Arch Otorhinolaryngol. 2001; 258 89-92
- 12 Davies A R, Froomes P R, French C J et al.. Randomized comparison of nasojejunal and nasogastric feeding in critically ill patients. Crit Care Med. 2002; 30 586-590
- 13 Taller A, Horvath E, Iliás L et al.. Technical modifications for improving the success rate of PEG tube placement in patients with head and neck cancer. Gastrointest Endosc. 2001; 54 633-636
- 14 Van Den Hazel S J, Mulder C JJ, Den Hartog G, Thies J E, Westhof W. A randomized trial of polyurethane and silicone percutaneous endoscopic gastrostomy catheters. Aliment Pharmacol Ther. 2000; 14 1273-1277
- 15 Sartori S, Trevisani L, Nielsen I, Tassinari D, Ceccotti P, Abbasciano V. Longevity of silicone and polyurethane catheters in long-term enteral feeding via percutaneous endoscopic gastrostomy. Aliment Pharmacol Ther. 2003; 17 853-856
- 16 Kadakia S C, Cassaday M, Shaffer R T. Prospective evaluation of Foley catheter as a replacement gastrostomy tube. Am J Gastroenterol. 1992; 87 1594-1597
- 17 Montecalvo M A, Steger K A, Farber H W The Critical Care Research Team et al. Nutritional outcome and pneumonia in critical care patients randomized to gastric versus jejunal tube feedings. Crit Care Med. 1992; 20 1377-1387
- 18 McIntyre R W. Small-bore feeding tubes. Crit Care Med. 1992; 20 309
- 19 Shang E, Geiger N, Sturm J W, Post S. Pump-assisted versus gravity-controlled enteral nutrition in long-term percutaneous endoscopic gastrostomy patients: a prospective controlled trial. JPEN J Parenter Enteral Nutr. 2003; 27 216-219
- 20 Daveluy W, Guimber D, Mention K et al.. Home enteral nutrition in children: an 11-year experience with 416 patients. Clin Nutr. 2005; 24 48-54
- 21 Planas M, Lecha M, García Luna P P Grupo de Trabajo NADYA-SENPE et al. [The year 2002 national registry on home-based enteral nutrition]. Nutr Hosp. 2005; 20 254-258
- 22 Heys S D, Walker L G, Smith I, Eremin O. Enteral nutritional supplementation with key nutrients in patients with critical illness and cancer: a meta-analysis of randomized controlled clinical trials. Ann Surg. 1999; 229 467-477
- 23 Moley J F, Morrison S D, Norton J A. Insulin reversal of cancer cachexia in rats. Cancer Res. 1985; 45 4925-4931
- 24 Chlebowski R T, Bucglave L, Grosvenor M et al.. Influence of hydrazine sulfate on abnormal carbohydrate metabolism in cancer patients with weight loss. Cancer Res. 1987; 44 857-861
Prashanth VarkeyM.Ch.
Division of Reconstructive Microsurgery, Jubilee Mission Hospital, Thrissur
Kerala, India 680005
eMail: drpvarkey@gmail.com