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Synlett 2011(18): 2605-2608  
DOI: 10.1055/s-0030-1289521
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© Georg Thieme Verlag Stuttgart ˙ New York

Synthetic Strategies toward the Guaiane Sesquiterpene Englerin A

William J. Chain*a,b
a Department of Chemistry, 2545 The Mall, University of Hawaii at Manoa, Honolulu, HI 96822, USA
b University of Hawaii Cancer Center, 651 Ilalo Street, Honolulu, HI 96813, USA
Fax: +1(808)9565908; e-Mail: chain@hawaii.edu;
Further Information

Publication History

Received 10 August 2011
Publication Date:
06 October 2011 (online)

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Abstract

Englerin A is a guaiane sesquiterpene with potent and selective growth inhibition activity against six human renal cancer cell lines. Since the disclosure of its structure in 2009, englerin A has been the subject of intense study by the synthetic organic chemistry community, and several elegant strategies have been developed for the total synthesis of this exciting natural product. These strategies are discussed herein.

Key words

terpenoids - total synthesis - antitumor agents - natural products - carbonyl

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