Englerin A is a guaiane sesquiterpene with potent and selective
growth inhibition activity against six human renal cancer cell lines.
Since the disclosure of its structure in 2009, englerin A has been
the subject of intense study by the synthetic organic chemistry
community, and several elegant strategies have been developed for
the total synthesis of this exciting natural product. These strategies
are discussed herein.
terpenoids - total synthesis - antitumor agents - natural products - carbonyl