Subscribe to RSS
DOI: 10.1055/s-0031-1271387
© Georg Thieme Verlag KG Stuttgart ˙ New York
Inzidenz, Risikofaktoren und Prävention der intestinalen Nahtinsuffizienz
Incidence of, Risk Factors for, and Prevention of Intestinal LeakagePublication History
Publication Date:
04 May 2011 (online)
![](https://www.thieme-connect.de/media/zblchir/201303/lookinside/thumbnails/10.1055-s-0031-1271387-1.jpg)
Zusammenfassung
Hintergrund: Die intestinale Anastomoseninsuffizienz stellt eine schwerwiegende Komplikation mit relevanter Morbidität und Mortalität dar. Material und Methoden: Auf Grundlage einer Literaturrecherche in Medline / PubMed werden die Daten zum Thema im Überblick dargestellt, kritisch bewertet und zusammengefasst. Ergebnisse und Schlussfolgerung: Neben der Optimierung der chirurgischen Technik spielen patientenabhängige Risikofaktoren eine wesentliche Rolle für die Entwicklung einer Anastomoseninsuffizienz. Dazu gehören Begleiterkrankungen, der Ernährungsstatus und die Einnahme bestimmter Medikamente oder eine vorangegangene Radio-Chemotherapie. Der Aufwand zur Optimierung dieser patientenbedingten Risikofaktoren findet im heutigen stationären Vergütungssystem keine Abbildung.
Abstract
Background: Intestinal anastomotic leakage represents a major complication in visceral surgery with relevant morbidity and mortality. Material and Methods: Based on a literature search in Medline / PubMed the available data are presented, critically reviewed and summarised. Results and Conclusion: Beside optimisation of surgical technique, patient-dependent risk factors – such as relevant comorbidity, certain medications or previous radiochemotherapy – play a major role in the development of anastomotic leakage. The effort for optimisation of these patient-dependent risk factors is not incorporated within the compensation scheme in German hospitals.
Schlüsselwörter
intestinale Ansatomoseninsuffizienz - intestinale Nahtinsuffizienz - Risikofaktoren - Inzidenz - Prävention
Key words
intestinal ansastomotic leakage - intestinal súrture failure - risk factors - incidence - prevention
Literatur
- 1 Wolf A M, Henne-Bruns D. [Anastomosis dehiscence in the gastrointestinal tract. Diagnosis and therapy]. Chirurg. 2002; 73 394-405 quiz 406-407
- 2 Khan A A, Wheeler J M, Cunningham C et al. The management and outcome of anastomotic leaks in colorectal surgery. Colorectal Dis. 2008; 10 587-592
- 3 Bruce J, Krukowski Z H, Al-Khairy G et al. Systematic review of the definition and measurement of anastomotic leak after gastrointestinal surgery. Br J Surg. 2001; 88 1157-1168
- 4 Hyman N, Manchester T L, Osler T et al. Anastomotic leaks after intestinal anastomosis: it‘s later than you think. Ann Surg. 2007; 245 254-258
- 5 Marusch F, Koch A, Schmidt U et al. Value of a protective stoma in low anterior resections for rectal cancer. Dis Colon Rectum. 2002; 45 1164-1171
- 6 Golub R, Golub R W, Cantu Jr R et al. A multivariate analysis of factors contributing to leakage of intestinal anastomoses. J Am Coll Surg. 1997; 184 364-372
- 7 Polat A, Nayci A, Polat G et al. Dexamethasone down-regulates endothelial expression of intercellular adhesion molecule and impairs the healing of bowel anastomoses. Eur J Surg. 2002; 168 500-506
- 8 Valente J F, Hricik D, Weigel K et al. Comparison of sirolimus vs. mycophenolate mofetil on surgical complications and wound healing in adult kidney transplantation. Am J Transplant. 2003; 3 1128-1134
- 9 Siewert J R, Stein H J, Bartels H. [Anastomotic leaks in the upper gastrointestinal tract]. Chirurg. 2004; 75 1063-1070
- 10 Welsch T, von Frankenberg M, Schmidt J et al. [Diagnosis and definition of anastomotic leakage from the surgeon‘s perspective.]. Chirurg. 2011; 82 48-55
- 11 Ng T, Vezeridis M P. Advances in the surgical treatment of esophageal cancer. J Surg Oncol. 2010; 101 725-729
- 12 Alanezi K, Urschel J D. Mortality secondary to esophageal anastomotic leak. Ann Thorac Cardiovasc Surg. 2004; 10 71-75
- 13 Holscher A H, Schroder W, Bollschweiler E et al. [How safe is high intrathoracic esophagogastrostomy?]. Chirurg. 2003; 74 726-733
- 14 Lang H, Piso P, Stukenborg C et al. Management and results of proximal anastomotic leaks in a series of 1 114 total gastrectomies for gastric carcinoma. Eur J Surg Oncol. 2000; 26 168-171
- 15 Meyer L, Meyer F, Dralle H et al. Insufficiency risk of esophagojejunal anastomosis after total abdominal gastrectomy for gastric carcinoma. Langenbecks Arch Surg. 2005; 390 510-516
- 16 Holscher A H, Vallbohmer D, Brabender J. The prevention and management of perioperative complications. Best Pract Res Clin Gastroenterol. 2006; 20 907-923
- 17 Ercan S, Rice T W, Murthy S C et al. Does esophagogastric anastomotic technique influence the outcome of patients with esophageal cancer?. J Thorac Cardiovasc Surg. 2005; 129 623-631
- 18 Orringer M B, Marshall B, Chang A C et al. Two thousand transhiatal esophagectomies: changing trends, lessons learned. Ann Surg. 2007; 246 363-372 discussion 372–374
- 19 Escofet X, Manjunath A, Twine C et al. Prevalence and outcome of esophagogastric anastomotic leak after esophagectomy in a UK regional cancer network. Dis Esophagus. 2010; 23 112-116
- 20 Tabatabai A, Hashemi M, Mohajeri G et al. Incidence and risk factors predisposing anastomotic leak after transhiatal esophagectomy. Ann Thorac Med. 2009; 4 197-200
- 21 Adam U, Makowiec F, Riediger H et al. [Pancreatic leakage after pancreas resection. An analysis of 345 operated patients]. Chirurg. 2002; 73 466-473
- 22 Mann C D, Palser T, Briggs C D et al. A review of factors predicting perioperative death and early outcome in hepatopancreaticobiliary cancer surgery. HPB (Oxford). 2010; 12 380-388
- 23 Schafer M, Mullhaupt B, Clavien P A. Evidence-based pancreatic head resection for pancreatic cancer and chronic pancreatitis. Ann Surg. 2002; 236 137-148
- 24 Sulberg D, Chromik A M, Koster O et al. [Prevention and management of postoperative complications in pancreatic surgery]. Zentralbl Chir. 2010; 135 129-138
- 25 Bassi C, Dervenis C, Butturini G et al. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery. 2005; 138 8-13
- 26 Goh B K, Tan Y M, Cheow P C et al. Outcome of distal pancreatectomy for pancreatic adenocarcinoma. Dig Surg. 2008; 25 32-38
- 27 Pratt W B, Maithel S K, Vanounou T et al. Clinical and economic validation of the International Study Group of Pancreatic Fistula (ISGPF) classification scheme. Ann Surg. 2007; 245 443-451
- 28 Adams D B. The pancreatic anastomosis: the danger of a leak, which anastomotic technique is better?. J Gastrointest Surg. 2009; 13 1182-1183
- 29 Hopt U T, Makowiec F, Adam U. [Leakage after biliary and pancreatic surgery]. Chirurg. 2004; 75 1079-1087
- 30 Bassi C, Falconi M, Molinari E et al. Duct-to-mucosa versus end-to-side pancreaticojejunostomy reconstruction after pancreaticoduodenectomy: results of a prospective randomized trial. Surgery. 2003; 134 766-771
- 31 Hosotani R, Doi R, Imamura M. Duct-to-mucosa pancreaticojejunostomy reduces the risk of pancreatic leakage after pancreatoduodenectomy. World J Surg. 2002; 26 99-104
- 32 Imaizumi T, Harada N, Hatori T et al. Stenting is unnecessary in duct-to-mucosa pancreaticojejunostomy even in the normal pancreas. Pancreatology. 2002; 2 116-121
- 33 Okamoto A, Tsuruta K. Fistulation method: simple and safe pancreaticojejunostomy after pancreatoduodenectomy. Surgery. 2000; 127 433-438
- 34 Peng S, Mou Y, Cai X et al. Binding pancreaticojejunostomy is a new technique to minimize leakage. Am J Surg. 2002; 183 283-285
- 35 Chromik A M, Sulberg D, Belyaev O et al. [Technical aspects of pancreatoenteric anastomosis.]. Chirurg. 2011; 82 14-25
- 36 Li-Ling J, Irving M. Somatostatin and octreotide in the prevention of postoperative pancreatic complications and the treatment of enterocutaneous pancreatic fistulas: a systematic review of randomized controlled trials. Br J Surg. 2001; 88 190-199
- 37 Buchler M, Friess H, Klempa I et al. Role of octreotide in the prevention of postoperative complications following pancreatic resection. Am J Surg. 1992; 163 125-130 discussion 130–131
- 38 Friess H, Beger H G, Sulkowski U et al. Randomized controlled multicentre study of the prevention of complications by octreotide in patients undergoing surgery for chronic pancreatitis. Br J Surg. 1995; 82 1270-1273
- 39 Montorsi M, Zago M, Mosca F et al. Efficacy of octreotide in the prevention of pancreatic fistula after elective pancreatic resections: a prospective, controlled, randomized clinical trial. Surgery. 1995; 117 26-31
- 40 Pederzoli P, Bassi C, Falconi M et al. Efficacy of octreotide in the prevention of complications of elective pancreatic surgery. Italian Study Group. Br J Surg. 1994; 81 265-269
- 41 Lowy A M, Lee J E, Pisters P W et al. Prospective, randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease. Ann Surg. 1997; 226 632-641
- 42 Yeo C J, Cameron J L, Lillemoe K D et al. Does prophylactic octreotide decrease the rates of pancreatic fistula and other complications after pancreaticoduodenectomy? Results of a prospective randomized placebo-controlled trial. Ann Surg. 2000; 232 419-429
- 43 Zeng Q, Zhang Q, Han S et al. Efficacy of somatostatin and its analogues in prevention of postoperative complications after pancreaticoduodenectomy: a meta-analysis of randomized controlled trials. Pancreas. 2008; 36 18-25
- 44 Alghamdi A A, Jawas A M, Hart R S. Use of octreotide for the prevention of pancreatic fistula after elective pancreatic surgery: a systematic review and meta-analysis. Can J Surg. 2007; 50 459-466
- 45 Poon R T, Fan S T. Decreasing the pancreatic leak rate after pancreaticoduodenectomy. Adv Surg. 2008; 42 33-48
- 46 Heidenhain C, Rosch R, Neumann U P. [Hepatobiliary anastomosis techniques.]. Chirurg. 2011; 82 7-13
- 47 Fujino Y, Suzuki Y, Ajiki T et al. Risk factors influencing pancreatic leakage and the mortality after pancreaticoduodenectomy in a medium-volume hospital. Hepatogastroenterology. 2002; 49 1124-1129
- 48 Srivastava S, Sikora S S, Pandey C M et al. Determinants of pancreaticoenteric anastomotic leak following pancreaticoduodenectomy. ANZ J Surg. 2001; 71 511-515
- 49 Suzuki Y, Fujino Y, Tanioka Y et al. Factors influencing hepaticojejunostomy leak following pancreaticoduodenal resection; importance of anastomotic leak test. Hepatogastroenterology. 2003; 50 254-257
- 50 Mathur A, Pitt H A, Marine M et al. Fatty pancreas: a factor in postoperative pancreatic fistula. Ann Surg. 2007; 246 1058-1064
- 51 Rosso E, Casnedi S, Pessaux P et al. The role of “fatty pancreas” and of BMI in the occurrence of pancreatic fistula after pancreaticoduodenectomy. J Gastrointest Surg. 2009; 13 1845-1851
- 52 de Castro S M, Kuhlmann K F, Busch O R et al. Incidence and management of biliary leakage after hepaticojejunostomy. J Gastrointest Surg. 2005; 9 1163-1171 discussion 1171-1173
- 53 Ozturk E, Can M F, Yagci G et al. Management and mid- to long-term results of early referred bile duct injuries during laparoscopic cholecystectomy. Hepatogastroenterology. 2009; 56 17-25
- 54 Sotiropoulos G C, Sgourakis G, Radtke A et al. Orthotopic liver transplantation: T-tube or not T-tube? Systematic review and meta-analysis of results. Transplantation. 2009; 87 1672-1680
- 55 Scatton O, Meunier B, Cherqui D et al. Randomized trial of choledochocholedochostomy with or without a T tube in orthotopic liver transplantation. Ann Surg. 2001; 233 432-437
- 56 Weiss S, Schmidt S C, Ulrich F et al. Biliary reconstruction using a side-to-side choledochocholedochostomy with or without T-tube in deceased donor liver transplantation: a prospective randomized trial. Ann Surg. 2009; 250 766-771
- 57 Egawa H, Inomata Y, Uemoto S et al. Biliary anastomotic complications in 400 living related liver transplantations. World J Surg. 2001; 25 1300-1307
- 58 Eckmann C, Kujath P, Schiedeck T H et al. Anastomotic leakage following low anterior resection: results of a standardized diagnostic and therapeutic approach. Int J Colorectal Dis. 2004; 19 128-133
- 59 Read T E, Mutch M G, Chang B W et al. Locoregional recurrence and survival after curative resection of adenocarcinoma of the colon. J Am Coll Surg. 2002; 195 33-40
- 60 Schmidt O, Merkel S, Hohenberger W. Anastomotic leakage after low rectal stapler anastomosis: significance of intraoperative anastomotic testing. Eur J Surg Oncol. 2003; 29 239-243
- 61 Willis S, Kasperk R, Braun J et al. Comparison of colonic J-pouch reconstruction and straight coloanal anastomosis after intersphincteric rectal resection. Langenbecks Arch Surg. 2001; 386 193-199
- 62 Kube R, Mroczkowski P, Steinert R et al. [Anastomotic leakage following bowel resections for colon cancer: multivariate analysis of risk factors]. Chirurg. 2009; 80 1153-1159
- 63 Marusch F, Koch A, Schmidt U et al. Wert des Protektiven Enterostoma bei tiefen anterioren Rektumresektionen.. In: Köckerling F, Lippert H, Gastinger I, Hrsg Fortschritte in der koloretalen Chirurgie.. Hannover: Sciene Med Dr. Sperber; 2002: 63-69
- 64 Willis S, Stumpf M. [Leakages after surgery of the lower gastrointestinal tract]. Chirurg. 2004; 75 1071-1078
- 65 Harris L J, Moudgill N, Hager E et al. Incidence of anastomotic leak in patients undergoing elective colon resection without mechanical bowel preparation: our updated experience and two-year review. Am Surg. 2009; 75 828-833
- 66 Huser N, Michalski C W, Erkan M et al. Systematic review and meta-analysis of the role of defunctioning stoma in low rectal cancer surgery. Ann Surg. 2008; 248 52-60
- 67 Tsunoda A, Tsunoda Y, Narita K et al. Quality of life after low anterior resection and temporary loop ileostomy. Dis Colon Rectum. 2008; 51 218-222
- 68 Utech M, Senninger N, Anthoni C. [Ostomy for stool deviation: indications and operative techniques]. Chirurg. 2009; 80 1171-1178 quiz 1179-1180
- 69 Kudszus S, Roesel C, Schachtrupp A et al. Intraoperative laser fluorescence angiography in colorectal surgery: a noninvasive analysis to reduce the rate of anastomotic leakage. Langenbecks Arch Surg. 2010; 395 1025-1030
- 70 Soeters P B, de Zoete J P, Dejong C H et al. Colorectal surgery and anastomotic leakage. Dig Surg. 2002; 19 150-155
- 71 Stumpf M, Cao W, Klinge U et al. Collagen distribution and expression of matrix metalloproteinases 1 and 13 in patients with anastomotic leakage after large-bowel surgery. Langenbecks Arch Surg. 2002; 386 502-506
- 72 Iancu C, Mocan L C, Todea-Iancu D et al. Host-related predictive factors for anastomotic leakage following large bowel resections for colorectal cancer. J Gastrointestin Liver Dis. 2008; 17 299-303
Prof. Dr. D. Henne-Bruns
Universitätsklinikum Ulm · Klinik für Allgemein-, Viszeral- und Transplantationschirurgie
Steinhoevelstr. 9
89075 Ulm
Deutschland
Phone: +49 / (0)7 31 / 50 00
Fax: +49 / (0)7 31 / 50 05 35 03
Email: sekretariat.chirurgie@uniklinik-ulm.de