Post-Cardiac Arrest Encephalopathy

Wei Xiong; Robert E Hoesch; Romergryko G Geocadin

doi:10.1055/s-0031-1277991

Seminars in Neurology, Inhaltsverzeichnis

Semin Neurol 2011; 31(2): 216-225
DOI: 10.1055/s-0031-1277991

Post-Cardiac Arrest Encephalopathy

Wei Xiong¹ , Robert E. Hoesch² , Romergryko G. Geocadin¹

¹Department of Neurology, Department of Neurosurgery, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland
²Neurosciences Critical Care; Department of Neurology, University of Utah School of Medicine, Clinical Neurosciences Center, Salt Lake City, Utah

Abstract

ABSTRACT

Brain injury continues to be a leading cause of mortality and morbidity in patients resuscitated after cardiac arrest. During periods of hypoxia and ischemia, numerous mechanisms contribute to the initial and secondary injury of the brain. Though many drugs and therapies have been evaluated for neuroprotection, only therapeutic hypothermia has been proven to be effective. Accurate prognostication after cardiac arrest is essential, and can be achieved with careful neurologic examination and several ancillary tests utilizing neurophysiology, neuroimaging, and biochemistry. Practice guidelines are now available for prognostication and postresuscitation care, with emphasis on improving survival and quality of life. Also reviewed are a wide spectrum of postarrest neurologic complications and their targeted treatments.

KEYWORDS

Cardiac arrest - anoxic - hypoxic - ischemic - hypoxic-ischemic - encephalopathy

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Referenzen

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Romergryko G GeocadinM.D.

Director, Neurosciences Critical Care Division; Department of Neurology, Department of Anesthesiology and Critical Care Medicine

Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287

eMail: rgeocad1@jhmi.edu