Planta Med 2012; 78(2): 186-188
DOI: 10.1055/s-0031-1280264
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Antifungal Sesquiterpenes from Cedrus deodara

Abha Chaudhary1 , Swati Sood2 , Pushpinder Kaur1 , Neeraj Kumar1 , Archana Thakur2 , Arvind Gulati2 , Bikram Singh1
  • 1Natural Plant Products Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
  • 2Plant Pathology and Microbiology Laboratory, Hill Area Tea Science Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India
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Publikationsverlauf

received May 30, 2011 revised September 5, 2011

accepted September 7, 2011

Publikationsdatum:
06. Oktober 2011 (online)

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Abstract

Two new sesquiterpenes, (E)-(2S,3S,6R)-atlantone-2,3-diol (1) and (E)-(2S,3S,6S)-atlantone-2,3,6-triol (2), along with two known sesquiterpenes, atlantolone (3) and (E)-α-atlantone (4), were isolated from Cedrus deodara Loud. The structures of the new compounds were elucidated on the basis of UV, IR, NMR, HR-ESI-QTOF-MS, and EI mass spectral studies. The n-hexane and chloroform extracts of sawdust and compounds 3 and 4 from the plant exhibited antifungal activity against Aspergillus flavus, A. niger, A. ochracoeus, A. parasiticus, and A. sydowii. A weak activity was also recorded against A. parasiticus and A. sydowii for compound 1, while Trichophyton rubrum was inhibited by compound 2 and the extracts.

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Dr. Bikram Singh

Natural Plant Products Division
CSIR-Institute of Himalayan Bioresource Technology
IHBT Communication No. 2104

Palampur, H. P., 176 061

India

Telefon: +91 18 94 23 04 26

Fax: +91 1894 23 04 33

eMail: bikramsingh@ihbt.res.in