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Synthesis 2011(24): 4003-4010
DOI: 10.1055/s-0031-1289606
DOI: 10.1055/s-0031-1289606
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Click Chemistry: An Efficient Synthesis of Heterocycles Substituted with Steroids, Saponins, and Digitalis Analogues
Further Information
Received
21 August 2011
Publication Date:
16 November 2011 (online)
Publication History
Publication Date:
16 November 2011 (online)
Abstract
The copper-catalyzed azide-alkyne cycloaddition (CuAAC) has been used for the construction of 1,2,3-triazole containing steroids in good to excellent yields. Combination of propargylic glycosides and steroidal azides as reaction partner allowed the synthesis of a privileged class of natural product analogues. The versatility of this protocol makes this chemistry a useful attractive approach for the synthesis of target molecules.
Key words
click chemistry - 1,2,3-triazole - sugars - steroids - saponins - digitalis
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