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Synthesis 2012(11): 1614-1624
DOI: 10.1055/s-0031-1289714
DOI: 10.1055/s-0031-1289714
PSP
© Georg Thieme Verlag
Stuttgart ˙ New York
Efficient Preparation of Tetrasubstituted Pyrazines Starting from Pyrazin-2(1H)-ones
Weitere Informationen
Publikationsverlauf
Received
4 January 2012
Publikationsdatum:
16. Februar 2012 (online)


Abstract
An efficient methodology for the synthesis of tetrasubstituted pyrazines starting from pyrazin-2(1H)-ones has been elaborated. Diversity in the functionalization and the beneficial effect of microwave irradiation throughout the methodology has been demonstrated.
Key words
palladium catalysis - copper catalysis - pyrazines - 3,5-dichloropyrazin-2(1H)-ones - microwaves - nucleosides