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Synthesis 2012(11): 1614-1624  
DOI: 10.1055/s-0031-1289714
PSP
© Georg Thieme Verlag Stuttgart ˙ New York

Efficient Preparation of Tetrasubstituted Pyrazines Starting from Pyrazin-2(1H)-ones

Sachin G. Modhaa, Jalpa C. Trivedia,b, Vaibhav P. Mehtaa,c, Denis S. Ermolat’eva, Erik V. Van der Eycken*a
a Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, 3001 Leuven, Belgium
e-Mail: erik.vandereycken@chem.kuleuven.be;
b Present address: Department of Chemistry, Shoolini University, Bhajol, Solan - 173 229, Himachal Pradesh, India
c Present address: Institut fÜr Organische and Biomoleculare Chemie, Georg-August-Universität Göttingen, Tamannstr. 2, 37077 Göttingen, Germany
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Publikationsverlauf

Received 4 January 2012
Publikationsdatum:
16. Februar 2012 (online)

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Abstract

An efficient methodology for the synthesis of tetrasubstituted pyrazines starting from pyrazin-2(1H)-ones has been elaborated. Diversity in the functionalization and the beneficial effect of microwave irradiation throughout the methodology has been demonstrated.

Key words

palladium catalysis - copper catalysis - pyrazines - 3,5-dichloropyrazin-2(1H)-ones - microwaves - nucleosides

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