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Synthesis 2012(7): 1037-1042  
DOI: 10.1055/s-0031-1289743
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Copper(I)-Catalyzed, One-Pot Synthesis of Multisubstituted Indoles from 2-Iodoanilines and Ethyl Buta-2,3-dienoate

Xianxue Wang, Jin Liu, Han Guo, Chao Ma, Xiai Gao, Kang Zhou, Guosheng Huang*
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
Fax: +86(931)8912582; e-Mail: hgs@lzu.edu.cn;
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Publication History

Received 30 December 2011
Publication Date:
14 March 2012 (online)

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Abstract

Reactions of 2-iodoanilines with ethyl buta-2,3-dienoate catalyzed by potassium carbonate and CuI in one pot generate the corresponding ethyl 2-methyl-1H-indole-3-carboxylate products in moderate yields under mild conditions.

Key words

indoles - aniline - allenes - copper - catalysis

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