Copper(I)-Catalyzed, One-Pot
Synthesis of Multisubstituted Indoles from 2-Iodoanilines
and Ethyl Buta-2,3-dienoate

Xianxue Wang; Jin Liu; Han Guo; Chao Ma; Xiai Gao; Kang Zhou; Guosheng Huang

doi:10.1055/s-0031-1289743

PAPER

Copper(I)-Catalyzed, One-Pot Synthesis of Multisubstituted Indoles from 2-Iodoanilines and Ethyl Buta-2,3-dienoate

Xianxue Wang, Jin Liu, Han Guo, Chao Ma, Xiai Gao, Kang Zhou, Guosheng Huang*
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
Fax: +86(931)8912582; e-Mail: hgs@lzu.edu.cn;

Abstract

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Abstract

Reactions of 2-iodoanilines with ethyl buta-2,3-dienoate catalyzed by potassium carbonate and CuI in one pot generate the corresponding ethyl 2-methyl-1H-indole-3-carboxylate products in moderate yields under mild conditions.

Key words

indoles - aniline - allenes - copper - catalysis

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Referenzen

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