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Synlett 2012(3): 413-417
DOI: 10.1055/s-0031-1290318
DOI: 10.1055/s-0031-1290318
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
A Regioselective Catalyst- and Additive-Free Synthesis of β-Keto Sulfones from Aryl Acetylenes and Sodium Arenesulfinates
Weitere Informationen
Received
18 July 2011
Publikationsdatum:
25. Januar 2012 (online)
Publikationsverlauf
Publikationsdatum:
25. Januar 2012 (online)
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Abstract
A facile and regioselective procedure for the preparation of β-keto sulfones has been developed through a simple reaction of aryl acetylenes and sodium arenesulfinates in nitroethane as a solvent at 50 ˚C. The procedure is catalyst- and additive-free and shows a wide range of functional-group tolerance. In this system the formation of new C-O and C-S bonds occurs in a one-pot procedure.
Key words
β-keto sulfone - aryl acetylene - sodium arene sulfinates - vinyl nitronic ester - sulfone - sulfinates salt
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