Download PDF
Synlett 2012(4): 642-643  
DOI: 10.1055/s-0031-1290334
SPOTLIGHT
© Georg Thieme Verlag Stuttgart ˙ New York

Zinc Borohydride

Ivson Lelis Gama*
Instituto de Química, Universidade Federal Fluminense, UFF, CEP: 24020-141 Niterói, Rio de Janeiro, Brazil
e-Mail: ivsonlelis@yahoo.com.br;
Further Information

Publication History

Publication Date:
13 February 2012 (online)

   Permissions and Reprints All articles of this category

Introduction

Zinc borohydride is a neutral reagent employed for the reduction of several types of carbonyl compounds. It is commercially available, but it is also easily prepared by reacting ZnCl2 with NaBH4. [¹] Kotsuki et al. described the selective reduction of thioesters in the presence of other functional groups using Zn(BH4)2 [¹] and Oishi and Nakata described the reduction of chiral β-keto esters with Zn(BH4)2 leading to the corresponding alcohols with high stereoselectivity. [²] This Spotlight summarizes further ­reactions of zinc borohydride.

    References

  • 1 Kotsuki H. Yoshimura N. Ushio Y. Ohtsuka T. Ochi M. Chem. Lett.  1986,  1003 
    Google Scholar
  • 2 Oishi T. Nakata T. Acc. Chem. Res.  1984,  17:  338 
    Google Scholar
  • 3 Ranu BC. Majee A. Sarkar A. J. Org. Chem.  1998,  63:  370 
    Google Scholar
  • 4 Yakura T. Yoshimoto Y. Ishida C. Mabuchi S. Tetrahedron  2007,  63:  4429 
    Google Scholar
  • 5 Dias LC. Fattori J. Perez CC. de Oliveira VM. Aguilar AM. Tetrahedron  2008,  64:  5891 
    Google Scholar
  • 6 Liu LX. Xião KJ. Huang PQ. Tetrahedron  2009,  65:  3834 
    Google Scholar
  • 7 Gao D. O’Doherty GA. J. Org. Chem.  2005,  70:  9932 
    Google Scholar
  • 8 Zhang D. Chen Z. Cai H. Zou X. J. Fluorine Chem.  2009,  130:  938 
    Google Scholar
  • 9 Hong S. Yang J. Weinreb SM. J. Org. Chem.  2006,  71:  2078 
    Google Scholar