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Synlett 2012; 23(11): 1625-1628
DOI: 10.1055/s-0031-1290379
DOI: 10.1055/s-0031-1290379
letter
An Enantioselective Mukaiyama Aldol Reaction as the Key Step towards the Tetrahydropyran Core of Psymberin via a γ-Butyrolactone Intermediate
Further Information
Publication History
Received: 30 March 2012
Accepted after revision: 23 April 2012
Publication Date:
14 June 2012 (online)
Abstract
We report an alternative synthetic route towards the tetrahydropyran core of psymberin. The key steps are a catalytic enantioselective Mukaiyama aldol reaction and a syn reduction, which allowed for the rapid assembly of a γ-lactone as a precursor for the central fragment of the natural product.
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