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Synlett 2012; 23(8): 1240-1244
DOI: 10.1055/s-0031-1290827
DOI: 10.1055/s-0031-1290827
letter
Copper-Catalyzed C–N Bond Formation with N-Heterocycles and Aryl Halides
Further Information
Publication History
Received: 04 January 2012
Accepted after revision: 07 March 2012
Publication Date:
26 April 2012 (online)
Abstract
The microwave-assisted, cuprous oxide catalyzed coupling of aryl bromides and iodides with imidazole, benzimidazole, pyrazole, or triazole was found to give a wide range of N-aryl heteroaromatic products in good to high yields. Aryl dibromides undergo selective monosubstitution even in the presence of large excess of N-heterocyclic nucleophiles which leaves the second aryl bromide functionality intact for further derivatization.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
-
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