Synlett 2012; 23(8): 1205-1208
DOI: 10.1055/s-0031-1290899
letter
© Georg Thieme Verlag Stuttgart · New York

New Method of Synthesis and Biological Evaluation of Some Combretastatin A-4 Analogues

Yulia B. Malysheva
a   Department of Organic Chemistry, Lobachevsky State University of Nizhni Novgorod, 23 Gagarin avenue, 603950 Nizhni Novgorod, Russian Federation, Fax: +7(831)4658592   eMail: afnn@rambler.ru
,
Sebastien Combes
b   UMR-CNRS 6264, Université d’Aix-Marseille, Faculté des Sciences Saint-Jérôme, Case 521, 13397 Marseille Cedex 20, France, Fax: +33(4)9128829   eMail: sebastien.combes@univ-provence.fr
,
Alexey Yu. Fedorov
a   Department of Organic Chemistry, Lobachevsky State University of Nizhni Novgorod, 23 Gagarin avenue, 603950 Nizhni Novgorod, Russian Federation, Fax: +7(831)4658592   eMail: afnn@rambler.ru
,
Paul Knochel
c   Department Chemie, Ludwig Maximilians Universität München, Butenandtstr. 5-13, Haus F, 81377 München, Germany, Fax: +49(89)218077680   eMail: knoch@cup.uni-muenchen.de   eMail: gavryushin@nanoscape.de
,
Andrei E. Gavryushin*
c   Department Chemie, Ludwig Maximilians Universität München, Butenandtstr. 5-13, Haus F, 81377 München, Germany, Fax: +49(89)218077680   eMail: knoch@cup.uni-muenchen.de   eMail: gavryushin@nanoscape.de
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Received: 02. Dezember 2011

Accepted after revision: 13. Januar 2012

Publikationsdatum:
26. April 2012 (online)


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Abstract

A series of novel combretastatin A-4 analogues was synthesized in 36–64% yields by Negishi cross-coupling reaction under mild conditions. The prepared compounds exhibit good cytotoxicity against HBL100 epithelial cell lines (IC50 = 0.022–10.31 µМ).

Supporting Information