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Synlett 2012; 23(10): 1481-1484
DOI: 10.1055/s-0031-1291012
DOI: 10.1055/s-0031-1291012
letter
Electrophilic Iodo-Mediated Cyclization in PEG under Microwave Irradiation: Easy Access to Highly Functionalized Furans and Pyrroles
Further Information
Publication History
Received: 17 February 2012
Accepted after revision: 23 March 2012
Publication Date:
25 May 2012 (online)
![](https://www.thieme-connect.de/media/synlett/201210/lookinside/thumbnails/10.1055-s-0031-1291012-1.jpg)
Abstract
The rapid and facile synthesis of highly substituted β-iodofurans and β-iodopyrroles is reported using a mixture of molecular iodine and a base in solid PEG 3400 as alternative, eco-friendly and nontoxic solvent under microwave irradiation, in a very short time. The heterocycles are efficiently recovered in good yields by a simple workup procedure, avoiding chromatographic purification.
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