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Synlett 2012; 23(10): 1511-1515
DOI: 10.1055/s-0031-1291014
DOI: 10.1055/s-0031-1291014
letter
Synthesis of 1,3-Disubstituted Azetidines via a Tandem Ring-Opening Ring-Closing Procedure
Further Information
Publication History
Received: 16 January 2012
Accepted after revision: 23 March 2012
Publication Date:
25 May 2012 (online)
Abstract
The synthesis of N-substituted symmetrical azetidines has been achieved in high yields via the reaction of primary amines undergoing an epoxide ring-opening reaction followed by an in situ ring-closing step.
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References and Notes
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- 13 CCDC 840439 (7) and CCDC 840438 (8) contain the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif, or by emailing data_request@ccdc.cam.ac.uk, or by contacting The Cambridge Crystallographic Data Centre, 12, Union Road, Cambridge CB2 1EZ, UK; fax: +44(1223)336033