Synlett 2012; 23(10): 1511-1515
DOI: 10.1055/s-0031-1291014
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 1,3-Disubstituted Azetidines via a Tandem Ring-Opening Ring-Closing Procedure

Andrea March-Cortijos
b   School of Chemistry, University of Manchester, Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester, M1 7DN, UK
,
Timothy J. Snape*
a   School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, Lancashire, PR1 2HE, UK, Fax: +44(1772)892929   eMail: tjsnape@uclan.ac.uk
,
Nicholas J. Turner
b   School of Chemistry, University of Manchester, Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester, M1 7DN, UK
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Publikationsverlauf

Received: 16. Januar 2012

Accepted after revision: 23. März 2012

Publikationsdatum:
25. Mai 2012 (online)


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Abstract

The synthesis of N-substituted symmetrical azetidines has been achieved in high yields via the reaction of primary amines undergoing an epoxide ring-opening reaction followed by an in situ ring-closing step.