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Synlett 2012; 23(11): 1621-1624
DOI: 10.1055/s-0031-1291163
DOI: 10.1055/s-0031-1291163
letter
Direct C–H Arylation of Quinones with Anilines
Further Information
Publication History
Received: 26 March 2012
Accepted after revision: 19 April 2012
Publication Date:
13 June 2012 (online)
Abstract
We discovered that anilines were suitable for the direct C–H arylation of benzoquinone in the presence of tert-butyl nitrite. This new reaction proceeds through the in situ formation of a diazonium hydroxide species. The coupling can be carried out at room temperature under neutral, additive-free, metal-free, and aqueous conditions, allowing an environmentally friendly procedure.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett. Included are experimental procedures and spectroscopic data.
- Supporting Information
-
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