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Semin Thromb Hemost 2012; 38(01): 95-101
DOI: 10.1055/s-0031-1300955
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Thrombin and Cancer: From Molecular Basis to Therapeutic Implications

Massimo Franchini
1   Department of Transfusion Medicine and Hematology, “C. Poma” Hospital, Mantova, Italy
,
Pier Mannuccio Mannucci
2   Scientific Direction, IRCCS Cà Granda Foundation Maggiore Hospital, Milan, Italy
› Author Affiliations
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Publication History

Publication Date:
07 February 2012 (online)

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Abstract

The relationship between cancer and thrombosis has been recognized for nearly 150 years. Although the mechanisms underlying this association are not completely understood, there are increasing evidences suggesting a pivotal role of thrombin in cancer biology. This review will focus on the most important pathways by which thrombin may affect cancer growth and dissemination. In addition, the potential role of congenital (i.e., hemophilia) and pharmaceutical (i.e., antithrombotic agents) anticoagulation in cancer incidence and survival will be investigated through the analysis of the published experimental and clinical studies.

Keywords

thrombin - cancer - hemophilia - anticoagulant
 

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