New Xanthone Glycosides from Comastoma pedunculatum

Yongqi Qiao; Yi Yuan; Baosong Cui; Ying Zhang; Hui Chen; Shuai Li; Yan Li

doi:10.1055/s-0032-1315079

Planta Medica, Inhaltsverzeichnis

Planta Med 2012; 78(14): 1591-1596
DOI: 10.1055/s-0032-1315079

Natural Product Chemistry

Letters

Georg Thieme Verlag KG Stuttgart · New York

New Xanthone Glycosides from Comastoma pedunculatum

Autor*innen

Yongqi Qiao

¹State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
Yi Yuan

¹State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
Baosong Cui

¹State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
Ying Zhang

¹State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
Hui Chen

¹State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
Shuai Li

¹State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
Yan Li

¹State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China

Abstract

Five new xanthone glycosides, comastomasides A–E (1–5), were isolated from aqueous ethanol extracts of the aerial portions of Comastoma pedunculatum. The structures of these compounds were elucidated by spectroscopic analysis methods. Compounds 1–5 were evaluated for their hepatoprotective activity and cytotoxicity against four human cancer cell lines by in vitro assays. Among them, compounds 3 and 5 exhibited potent hepatoprotective activity. However, none of the compounds displayed cytotoxic activity.

Key words

Comastoma pedunculatum - Gentianaceae - xanthone glycosides - hepatoprotective activity

Volltext

Referenzen

References
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Zusatzmaterial

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