New Phenolic Compounds with Anti-adipogenic Activity from the Aerial Parts of Pulsatilla koreana

Abstract

Three new phenolic compounds, pulsatillosides A (1), B (2), and C (3), were isolated from the aerial parts of Pulsatilla koreana, together with two known flavonoid glycosides, trans-tiliroside (4) and kaempferol-3-O-β-glycoside (5). The structures of the isolated compounds were determined on the basis of spectroscopic analysis including 1D, 2D NMR and HR-MS. Among the isolated compounds, compounds 1–3 significantly inhibited adipocyte differentiation as measured by fat accumulation in 3 T3-L1 cells using Oil Red O staining.

Key words

Pulsatilla koreana - Ranunculaceae - pulsatillosides A–C - adipocyte differentiation

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