Synthesis 2012; 44(20): 3109-3128
DOI: 10.1055/s-0032-1316778
review
© Georg Thieme Verlag Stuttgart · New York

1,6-Conjugate Addition of Nucleophiles to α,β,γ,δ-Diunsaturated Systems

Eduarda M. P. Silva
Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal   Fax: +351(234)370714   eMail: artur.silva@ua.pt
,
Artur M. S. Silva*
Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal   Fax: +351(234)370714   eMail: artur.silva@ua.pt
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received: 01. Juli 2012

Accepted after revision: 07. August 2012

Publikationsdatum:
12. September 2012 (online)


Abstract

Herein, an overview of the most important developments and concepts related to the 1,6-conjugate addition reactions are reviewed.

1 Introduction

2 Transition-Metal-Catalyzed 1,6-Conjugate Additions

2.1 Copper-Mediated Reactions

2.2 Iron-Mediated Reactions

2.3 Rhodium- and Iridium-Mediated Reactions

3 Organocatalyzed 1,6-Conjugate Additions

4 Other Methods

5 Conclusions