Synthesis 2012; 44(24): 3811-3814
DOI: 10.1055/s-0032-1316813
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Indoles by Copper-Catalyzed Heteroannulation of o-Aminophenylboronic Acid Pinacol Esters with β-Keto Esters

Ala Bunescu
Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, BCH 5304, 1015 Lausanne, Switzerland   Fax: +41(21)6939740   Email: jieping.zhu@epfl.ch
,
Qian Wang
Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, BCH 5304, 1015 Lausanne, Switzerland   Fax: +41(21)6939740   Email: jieping.zhu@epfl.ch
,
Jieping Zhu*
Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, BCH 5304, 1015 Lausanne, Switzerland   Fax: +41(21)6939740   Email: jieping.zhu@epfl.ch
› Author Affiliations
Further Information

Publication History

Received: 03 October 2012

Accepted after revision: 30 October 2012

Publication Date:
15 November 2012 (online)


Abstract

Copper-catalyzed coupling of o-aminophenylboronic acid pinacol esters with β-keto esters afforded, under mild base-free oxidative conditions, 2,3-disubstituted indoles featuring a key Chan–Lam-type carbon–carbon bond-forming reaction.

Supporting Information