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DOI: 10.1055/s-0032-1317416
Biomimetic Syntheses of the Flindersial Alkaloids
Publication History
Received: 16 August 2012
Accepted after revision: 20 September 2012
Publication Date:
19 October 2012 (online)
Abstract
The flindersial alkaloids have a potentially novel mechanism for antimalarial activity. The recently disclosed flinderoles were postulated to be derived through dimerization of the natural product borrerine in a manner similar to their structural isomers, the borreverines. Recent work by the authors has shown that the flindersial alkaloids share a common biosynthetic origin to that of borrerine. The application of this insight has resulted in the synthesis of naturally occurring flindersial alkaloids with controlled formation of the structural isomer. Only three synthetic steps from tryptamine are needed for any of the natural products.
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