Sulfoximine- and Sulfilimine-Based DAPSON Analogues; Syntheses and Bioactivities

Abstract

Sulfoximine- and sulfilimine-based diamino-diphenyl sulfone (DAPSON) analogues have been prepared and their COX-1 and COX-2 inhibition potencies as well as LTB₄ and TNF binding properties were studied. Furthermore, their antiproliferative activities on cancer cell growth were investigated. Neither compounds showed significant bioactivities.

Key words

drug discovery - cancer - oxidation - sulfoximine - sulfil­imine

• References

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These assays were performed by Ricerca Biosciences, Chicago, USA. Methods:
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