We developed a copper(II) triflate–bisphosphine complex catalyzed olefin migration
and Prins cyclization which lead to the synthesis of substituted tetrahydropyran derivatives.
The protocol is convenient and a variety of substituted tetrahydropyrans were obtained
in good to excellent yields with excellent diastereoselectivities.
Key words
tetrahydropyrans - olefin migration - Prins cyclization - diastereoselective - metal-ligand
catalyzed