Synlett 2012; 23(19): 2822-2826
DOI: 10.1055/s-0032-1317520
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© Georg Thieme Verlag Stuttgart · New York

A Concise Total Synthesis of (+)-Cladospolide D

Debjani Si
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India   Fax: +91(22)25723480   Email: kpk@chem.iitb.ac.in
,
Krishna P. Kaliappan*
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India   Fax: +91(22)25723480   Email: kpk@chem.iitb.ac.in
› Author Affiliations
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Publication History

Received: 05 September 2012

Accepted after revision: 08 October 2012

Publication Date:
09 November 2012 (online)


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Dedicated to Professor M. Periasamy (University of Hyderabad) on the occasion of his 60th birthday

Abstract

A short and convergent total synthesis of (+)-cladospolide D is delineated, which involves olefin cross metathesis and furan oxidation to access the γ-oxo-α,β-unsaturated acid and Yamaguchi lactonization to construct the 12-membered ring as key steps.

Supporting Information