Mercaptoacetic Acid

Introduction

Mercaptoacetic acid (3), also known as thioglycolic acid, is a liquid miscible with water and with most organic solvents such as alcohols, ether, chloroform and benzene.[ ¹ ] It is widely described in the literature, especially as a substrate for the synthesis of pharmacologically active heterocycles[ ² ] including 1,3-thiazolidin-4-ones,[ ³ ] 1,4-thiazepines[ ⁴ ] and thiazoles.[ ⁵ ] It is also used for the formation of spiro derivatives,[ ⁶ ] in multicomponent reactions, and in removing the nosyl protecting group from amine functions of α-amino acids.[ ⁷ ]

• References

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