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Planta Med 2012; 78(18): 1971-1975
DOI: 10.1055/s-0032-1327875
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

Unusual 9,19 : 24,32-Dicyclotetracyclic Triterpenoids from Lygodium japonicum

Qing-hua Han
1   School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
,
Xin Liu
1   School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
,
Wen-qing Yao
2   School of Chemistry and Biological Science, University of Science and Technology, Beijing, China
,
Zhong-bin Cheng
1   School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
,
Ting-ting Lin
1   School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
,
Ching Song
2   School of Chemistry and Biological Science, University of Science and Technology, Beijing, China
,
Sheng Yin
1   School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 10. Juli 2012
revised 25. September 2012

accepted 01. Oktober 2012

Publikationsdatum:
15. November 2012 (online)

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Abstract

Lygodipenoids A (1) and B (2), two novel C33 tetracyclic triterpenoids with a new 9,19 : 24,32-dicyclopropane skeleton, were isolated from the whole grass of Lygodium japonicum. Their structures were elucidated by spectroscopic and chemical means. Compounds 1 and 2 were tested in transfected cultured human embryonic kidney 293 HEK293 cells for an agonist assay, and compound 1 was identified as a partial agonist for liver X receptor α.

Key words

>Lygodium japonicum (Thunb.) Sw. - Lygodiaceae - 9,19 : 24,32-dicyclotetracyclic triterpenoid - liver X receptor α

Supporting Information

 

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