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Geburtshilfe Frauenheilkd 2012; 72(12): 1117-1129
DOI: 10.1055/s-0032-1328084
Review
Georg Thieme Verlag KG Stuttgart · New York

Advances in Breast Cancer – Looking Back over the Year

Fortschritte beim Mammakarzinom – ein Rückblick auf das Jahr
D. Lüftner
1   Medizinische Klinik und Poliklinik II, Campus Charité Mitte, Berlin
,
M. P. Lux
2   Frauenklinik, Universitätsklinikum Erlangen, Erlangen
,
N. Maass
3   Department of Gynecology and Obstetrics, University Hospital Aachen
,
F. Schütz
4   Frauenklinik, Universitätsklinikum Heidelberg, Heidelberg
,
I. Schwidde
5   Klinik für Senologie/Brustzentrum, Klinikum Essen-Mitte, Essen
,
P. A. Fasching
6   Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen
,
T. Fehm
7   Department of Obstetrics and Gynecology, University Tübingen, Tübingen
,
W. Janni
8   Frauenklinik, Klinikum der Universität Ulm, Ulm
,
S. Kümmel
5   Klinik für Senologie/Brustzentrum, Klinikum Essen-Mitte, Essen
,
H.-C. Kolberg
9   Klinik für Gynäkologie und Geburtshilfe, Marienhospital Bottrop, Bottrop
› Author Affiliations
Further Information

Publication History

received 02 December 2012
revised 03 December 2012

accepted 03 December 2012

Publication Date:
19 December 2012 (online)

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Abstract

Treatment options as well as the characteristics for therapeutic decisions in patients with primary and advanced breast cancer are increasing in number and variety. New targeted therapies in combination with established chemotherapy schemes are broadening the spectrum, yet not every new, promising combination achieves a better result. New data from the field of pharmacogenomics point to prognostic and predictive factors that take not only the properties of the tumour but also the genetic disposition of the patient into consideration. Current therapeutic decision-making is thus based on a combination of classical clinical and modern molecular biomarkers. Health-economic concerns are also being taken into consideration more frequently, meaning political decisions may also become a factor. This review presents the trends over the past year.

Zusammenfassung

Die Behandlungsoptionen und auch die Charakteristika zur Therapieentscheidung der Patientin mit einem primären und fortgeschrittenen Mammakarzinom werden immer vielfältiger. Neue zielgerichtete Therapien in Kombination mit etablierten Chemotherapien erweitern das Spektrum, doch potenziell vielversprechende Kombinationen bringen nicht immer ein besseres Ergebnis. Neueste Daten aus der Pharmakogenomik weisen auf Prognose- und Prädiktivfaktoren hin, die nicht nur die Eigenschaften des Tumors, sondern auch die vererbbaren genetischen Eigenschaften der Patientin berücksichtigen. Die aktuelle Therapieentscheidung ist somit mittlerweile eine Kombination aus klassischerweise klinischen und modernen molekularen Biomarkern. Immer häufiger werden auch gesundheitsökonomische Aspekte berücksichtigt, sodass auch gesundheitspolitische Überlegungen eine Rolle spielen können. Diese Übersichtsarbeit stellt die Entwicklung des vergangenen Jahres dar.

Key words

breast cancer therapy - molecular biomarkers - targeted therapy - trastuzumab - T-DM1 - everolimus

Schlüsselwörter

Mammakarzinombehandlung - molekulare Biomarker - zielgerichtete Therapie - Trastuzumab - T-DM1 - Everolimus

Supporting Information

 

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