Neuroprotection of a Novel Synthetic Caffeic Acid-Syringic Acid
                    Hybrid Compound against Experimentally Induced Transient Cerebral Ischemic
                    Damage

In Hye Kim; Bing Chun Yan; Joon Ha Park; Go Heum Yeun; Yongbae Yim; Ji Hyeon Ahn; Jae-Chul Lee; In Koo Hwang; Jun Hwi Cho; Young-Myeong Kim; Yun Lyul Lee; Jeong Ho Park; Moo-Ho Won

doi:10.1055/s-0032-1328211

Planta Medica, Table of Contents

Planta Med 2013; 79(05): 313-321
DOI: 10.1055/s-0032-1328211

Biological and Pharmacological Activity

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Neuroprotection of a Novel Synthetic Caffeic Acid-Syringic Acid Hybrid Compound against Experimentally Induced Transient Cerebral Ischemic Damage

In Hye Kim^*

¹Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea

,

Bing Chun Yan^*

¹Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea

,

Joon Ha Park

¹Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea

,

Go Heum Yeun

²Department of Chemical and Biological Engineering, Hanbat National University, Daejeon, South Korea

,

Yongbae Yim

²Department of Chemical and Biological Engineering, Hanbat National University, Daejeon, South Korea

,

Ji Hyeon Ahn

³Laboratory of Neuroscience, Department of Physical Therapy, College of Rehabilitation Science, Daegu University, Gyeongsan, South Korea

,

Jae-Chul Lee

¹Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea

,

In Koo Hwang

⁴Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, South Korea

,

Jun Hwi Cho

⁵Department of Emergency Medicine and Institute of Medical Sciences, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea

⁶Institute of Medical Sciences, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea

,

Young-Myeong Kim

⁷Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, South Korea

,

Yun Lyul Lee

⁸Department of Physiology and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, South Korea

,

Jeong Ho Park

²Department of Chemical and Biological Engineering, Hanbat National University, Daejeon, South Korea

,

Moo-Ho Won

¹Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea

⁶Institute of Medical Sciences, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea

› Author Affiliations

Abstract

We investigated effects of caffeic acid, syringic acid, and their synthesis on transient cerebral ischemic damage in the gerbil hippocampal CA1 region. In the 10 mg/kg caffeic acid-, syringic acid-, and 20 mg/kg syringic-treated ischemia groups, we did not find any significant neuroprotection in the ischemic hippocampal CA region. In the 20 mg/kg caffeic acid- and 10 mg/kg caffeic acid-syringic acid-treated ischemia groups, moderate neuroprotection was found in the hippocampal CA1 region. In the 20 mg/kg caffeic acid-syringic acid-treated ischemia group, a strong neuroprotective effect was found in the ischemic hippocampal CA1 region: about 89 % of hippocampal CA1 region pyramidal neurons survived. We also observed changes in glial cells (astrocytes and microglia) in the ischemic hippocampal CA1 region in all the groups. Among them, the distribution pattern of the glial cells was only in the 20 mg/kg caffeic acid-syringic acid-treated ischemia group similar to that in the sham group (control). In brief, 20 mg/kg caffeic acid-syringic acid showed a strong neuroprotective effect with an inhibition of glia activation in the hippocampal CA1 region induced by transient cerebral ischemia.

Key words

natural phenolic compounds - ischemic stroke - neuroprotection - hippocampus

Full Text

References

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