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Planta Med 2013; 79(05): 313-321
DOI: 10.1055/s-0032-1328211
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Neuroprotection of a Novel Synthetic Caffeic Acid-Syringic Acid Hybrid Compound against Experimentally Induced Transient Cerebral Ischemic Damage

In Hye Kim   *
1   Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea
,
Bing Chun Yan   *
1   Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea
,
Joon Ha Park
1   Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea
,
Go Heum Yeun
2   Department of Chemical and Biological Engineering, Hanbat National University, Daejeon, South Korea
,
Yongbae Yim
2   Department of Chemical and Biological Engineering, Hanbat National University, Daejeon, South Korea
,
Ji Hyeon Ahn
3   Laboratory of Neuroscience, Department of Physical Therapy, College of Rehabilitation Science, Daegu University, Gyeongsan, South Korea
,
Jae-Chul Lee
1   Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea
,
In Koo Hwang
4   Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, South Korea
,
Jun Hwi Cho
5   Department of Emergency Medicine and Institute of Medical Sciences, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea
6   Institute of Medical Sciences, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea
,
Young-Myeong Kim
7   Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, South Korea
,
Yun Lyul Lee
8   Department of Physiology and Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, South Korea
,
Jeong Ho Park
2   Department of Chemical and Biological Engineering, Hanbat National University, Daejeon, South Korea
,
Moo-Ho Won
1   Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, South Korea
6   Institute of Medical Sciences, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea
› Author Affiliations
Further Information

Publication History

received 22 July 2012
revised 15 January 2013

accepted 16 January 2013

Publication Date:
14 February 2013 (online)

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Abstract

We investigated effects of caffeic acid, syringic acid, and their synthesis on transient cerebral ischemic damage in the gerbil hippocampal CA1 region. In the 10 mg/kg caffeic acid-, syringic acid-, and 20 mg/kg syringic-treated ischemia groups, we did not find any significant neuroprotection in the ischemic hippocampal CA region. In the 20 mg/kg caffeic acid- and 10 mg/kg caffeic acid-syringic acid-treated ischemia groups, moderate neuroprotection was found in the hippocampal CA1 region. In the 20 mg/kg caffeic acid-syringic acid-treated ischemia group, a strong neuroprotective effect was found in the ischemic hippocampal CA1 region: about 89 % of hippocampal CA1 region pyramidal neurons survived. We also observed changes in glial cells (astrocytes and microglia) in the ischemic hippocampal CA1 region in all the groups. Among them, the distribution pattern of the glial cells was only in the 20 mg/kg caffeic acid-syringic acid-treated ischemia group similar to that in the sham group (control). In brief, 20 mg/kg caffeic acid-syringic acid showed a strong neuroprotective effect with an inhibition of glia activation in the hippocampal CA1 region induced by transient cerebral ischemia.

Key words

natural phenolic compounds - ischemic stroke - neuroprotection - hippocampus

* In Hye Kim and Bing Chun Yan contributed equally to this study.