Download PDF
Klin Monbl Augenheilkd 2013; 230(9): 920-928
DOI: 10.1055/s-0032-1328641
Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Vitreomakuläres Traktionssyndrom (VMTS)

Vitreomacular Traction Syndrome (VMTS)
M. M. Maier
Augenklinik, Klinikum rechts der Isar, Technische Universität München (TUM)
,
N. Feucht
Augenklinik, Klinikum rechts der Isar, Technische Universität München (TUM)
,
S. Burzer
Augenklinik, Klinikum rechts der Isar, Technische Universität München (TUM)
,
C. P. Lohmann
Augenklinik, Klinikum rechts der Isar, Technische Universität München (TUM)
› Author Affiliations
Further Information

Publication History

eingereicht 20 December 2012

akzeptiert 06 May 2013

Publication Date:
10 July 2013 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Das vitreomakuläre Traktionssyndrom ist gekennzeichnet durch eine anomale hintere Glaskörperabhebung (AHGA) mit persistierender symptomatischer Glaskörperadhäsion an der Makula. Diese Adhäsion bedingt eine Verdickung der Makula, ein Makulaödem und damit eine verminderte Sehschärfe. Moderne bildgebende Verfahren wie das hochauflösende Spectral Domain OCT (SD-OCT) ermöglichen einen immer detaillierteren Einblick in die retinale Mikrostruktur und den vitreoretinalen Übergang. Vitreomakuläre Adhärenzen und Traktionen und deren Auswirkung auf die Netzhaut lassen sich damit genau darstellen. Das vitreomakuläre Traktionssyndrom wurde und wird bis heute chirurgisch behandelt. In Studien zur pharmakologischen Vitreolyse konnte bei Patienten mit symptomatischer vitreomakulärer Adhäsion und Traktion ein therapeutischer Effekt nachgewiesen werden. Diese Studienergebnisse stellen einen wichtigen Schritt hin zur pharmakologischen Behandlung der vitreomakulären Adhäsion mit Traktion dar.

Abstract

In vitreomacular traction syndrome (VMTS) an anomalous posterior vitreous detachment (APVD) with persistant symptomatic vitreoretinal adhesion is seen. The adhesion leads to a thickened macula, to macular oedema and a reduction of BCVA. Modern imaging techniques like spectral domain OCT (SD-OCT) allow a detailed imaging of the retinal microstructure and the vitreoretinal interface. Vitreomacular adhesions and their effect on the retina can be visualised. Until now, the treatment option for VMTS was and is vitreoretinal surgery. In studies pharmacological vitreolysis has shown a therapeutic effect in patients with symptomatic adhesion and traction. The results of these studies represent an important step towards a pharmacological treatment of VMTS.

Schlüsselwörter

vitreomakuläres Traktionssyndrom - pathologische hintere Glaskörperabhebung - pharmakologische Vitreolyse - Ocriplasmin

Key words

vitreomacular traction syndrome - anomalous posterior vitreous detachment (APVD) - pharmacological vitreolysis - ocriplasmin
 

  • Literatur

  • 1 Reese AB, Jones IS, Cooper WC. Vitreomacular traction syndrome confirmed histologically. Am J Ophthalmol 1970; 69: 975-977
    CrossrefPubMedSearch in Google Scholar
  • 2 Barak Y, Ihnen MA, Schaal S. Spectral domain optical coherence tomography in the diagnosis and management of vitreoretinal interface pathologies. J Ophthalmol 2012; 2012: 876472
    PubMedSearch in Google Scholar
  • 3 Sebag J, Wang MY. Combined Spectral-Domain optical Coherence Tomography/Scanning Laser Ophthalmoscopy Imaging of vitreous and the vitreo-retinal Interface, medical Retina, Focus on retinal Imaging. Holz FG, Spaide RF, eds. Essentials in Ophthalmology. Berlin, Heidelberg: Springer Verlag; 2010: 157-168
    Search in Google Scholar
  • 4 Benz MS, Packo KH, Gonzalez V et al. A placebo-controlled trial of microplasmin intravitreous injection to facilitate posterior vitreous detachment before vitrectomy. Ophthalmology 2010; 117: 791-797
    CrossrefPubMedSearch in Google Scholar
  • 5 de Smet MD, Gandorfer A, Stalmans P et al. Microplasmin intravitreal administration in patients with vitreomacular traction scheduled for vitrectomy: the MIVI I trial. Ophthalmology 2009; 116: 1349-1355
    CrossrefPubMedSearch in Google Scholar
  • 6 Gandorfer A. Pharmakologische Vitreolyse. Klin Monatsbl Augenheilkd 2011; 228: 201-207
    Thieme ConnectPubMedSearch in Google Scholar
  • 7 Haller JA. The vitreomacular interface and Ocriplamin. Retina Subspecialty Day AAO 2011.
    PubMed
  • 8 Stalmans P, Benz MS, Gandorfer A et al. MIVI-TRUST Study Group. Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes. N Engl J Med 2012; 367: 606-615
    CrossrefPubMedSearch in Google Scholar
  • 9 Sebag J. Anomalous posterior vitreous detachment: a unifying concept in vitreo-retinal disease. Graefes Arch Clin Exp Ophthalmol 2004; 242: 690-698
    CrossrefPubMedSearch in Google Scholar
  • 10 Gandorfer A, Rohleder M, Kampik A. Epiretinal pathology of vitreomacular traction syndrome. Br J Ophthalmol 2002; 86: 902-909
    CrossrefPubMedSearch in Google Scholar
  • 11 Johnson MW. Posterior vitreous detachment: evolution and complications of its early stages. Am J Ophthalmol 2010; 149: 371-382
    CrossrefPubMedSearch in Google Scholar
  • 12 Koizumi H, Spaide RF, Fisher YL et al. Three-dimensional evaluation of vitreomacular traction and epiretinal membrane using spectral-domain optical coherence tomography. Am J Ophthalmol 2008; 145: 509-517
    CrossrefPubMedSearch in Google Scholar
  • 13 Sebag J, Balazs EA. Morphology and ultrastructure of human vitreous fibers. Invest Ophthalmol Vis Sci 1989; 30: 1867-1871
    PubMedSearch in Google Scholar
  • 14 Sebag J. Age-related differences in the human vitreoretinal interface. Arch Ophthalmol 1991; 109: 966-971
    CrossrefPubMedSearch in Google Scholar
  • 15 Sebag J, Gupta P, Rosen RR et al. Macular holes and macular pucker: the role of vitreoschisis as imaged by optical coherence tomography/scanning laser ophthalmoscopy. Trans Am Ophthalmol Soc 2007; 105: 121-129 discussion 129–131
    PubMedSearch in Google Scholar
  • 16 Sebag J. Molecular biology of pharmacologic vitreolysis. Trans Am Ophthalmol Soc 2005; 103: 473-494
    PubMedSearch in Google Scholar
  • 17 Schneider EW, Johnson MW. Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review. Clin Ophthalmol 2011; 5: 1151-1165
    PubMedSearch in Google Scholar
  • 18 Bishop PN. Structural macromolecules and supramolecular organisation of the vitreous gel. Prog Retin Eye Res 2000; 19: 323-344
    CrossrefPubMedSearch in Google Scholar
  • 19 Kohno T, Sorgente N, Ishibashi T et al. Immunofluorescent studies of fibronectin and laminin in the human eye. Invest Ophthalmol Vis Sci 1987; 28: 506-514
    PubMedSearch in Google Scholar
  • 20 Ponsioen TL, van Luyn MJ, van der Worp RJ et al. Collagen distribution in the human vitreoretinal interface. Invest Ophthalmol Vis Sci 2008; 49: 4089-4095
    CrossrefPubMedSearch in Google Scholar
  • 21 Terranova VP, Rohrbach DH, Martin GR. Role of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagen. Cell 1980; 22: 719-726
    CrossrefPubMedSearch in Google Scholar
  • 22 Engvall E, Ruoslahti E, Miller EJ. Affinity of fibronectin to collagens of different genetic types and to fibrinogen. J Exp Med 1978; 147: 1584-1595
    CrossrefPubMedSearch in Google Scholar
  • 23 Uchino E, Uemura A, Ohba N. Initial stages of posterior vitreous detachment in healthy eyes of older persons evaluated by optical coherence tomography. Arch Ophthalmol 2001; 119: 1475-1479
    CrossrefPubMedSearch in Google Scholar
  • 24 Uchino E, Uemura A, Doi N et al. Postsurgical evaluation of idiopathic vitreomacular traction syndrome by optical coherence tomography. Am J Ophthalmol 2001; 132: 122-123
    CrossrefPubMedSearch in Google Scholar
  • 25 Schwab C, Ivastinovic D, Borkenstein A et al. Prevalence of early and late stages of physiologic PVD in emmetropic elderly population. Acta Ophthalmol 2012; 90: e179-e184
    CrossrefPubMedSearch in Google Scholar
  • 26 Sivaprasad S, Ockrim Z, Massaoutis P et al. Posterior hyaloid changes following intravitreal triamcinolone and macular laser for diffuse diabetic macular edema. Retina 2008; 28: 1435-1442
    CrossrefPubMedSearch in Google Scholar
  • 27 Krebs I, Brannath W, Glittenberg C et al. Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration?. Am J Ophthalmol 2007; 144: 741-746
    CrossrefPubMedSearch in Google Scholar
  • 28 Maier M, Pfrommer S, Burzer S et al. [Vitreomacular interface and posterior vitreomacular adhesion in exudative age-related macular degeneration (AMD): an OCT-based comparative study]. Klin Monatsbl Augenheilkd 2012; 229: 1030-1035
    Thieme ConnectPubMedSearch in Google Scholar
  • 29 Akiba J, Quiroz MA, Trempe CL. Role of posterior vitreous detachment in idiopathic macular holes. Ophthalmology 1990; 97: 1610-1613
    PubMedSearch in Google Scholar
  • 30 Sonmez K, Capone A, Trese MT et al. Vitreomacular traction syndrome: impact of anatomical configuration on anatonical and visual outcomes. Retina 2008; 28: 1207-1214
    CrossrefPubMedSearch in Google Scholar
  • 31 Bottós JM, Elizalde J, Rodrigues EB et al. Current concepts in vitreomacular traction syndrome. Curr Opin Ophthalmol 2012; 23: 195-201
    CrossrefPubMedSearch in Google Scholar
  • 32 Ivastinovic D, Schwab C, Borkenstein A et al. Evolution of early changes at the vitreoretinal interface after cataract surgery determined by optical coherence tomography and ultrasonography. Am J Ophthalmol 2012; 153: 705-709
    CrossrefPubMedSearch in Google Scholar
  • 33 Mirshahi A, Hoehn F, Lorenz K et al. Incidence of posterior vitreous detachment after cataract surgery. J Cataract Refract Surg 2009; 35: 987-991
    CrossrefPubMedSearch in Google Scholar
  • 34 Rouvas A, Petrou P, Ladas I et al. Spontaneous resolution of vitreomacular traction following ranibizumab (Lucentis) injection. Eur J Ophthalmol 2008; 18: 301-303
    PubMedSearch in Google Scholar
  • 35 McDonald HR, Johnson RN, Schatz H. Surgical results in vitreomacular traction syndrome. Ophthalmology 1994; 101: 1397-1403
    PubMedSearch in Google Scholar
  • 36 Koerner F, Garweg J. Vitrectomy for macular pucker and vitreomacular traction syndrome. Doc Ophthalmol 1999; 97: 449-458
    CrossrefPubMedSearch in Google Scholar
  • 37 Witkin AJ, Patron ME, Castro LC et al. Anatomic and visual outcomes of vitrectomy for vitreomacular traction syndrome. Ophthalmic Surg Lasers Imaging 2010; 41: 425-431
    CrossrefPubMedSearch in Google Scholar
  • 38 Issa SA, Connor A, Habib M, Steel DH. Comparison of retinal breaks observed during 23 gauge transconjunctival vitrectomy versus conventional 20 gauge surgery for proliferative diabetic retinopathy. Clin Ophthalmol 2011; 20: 109-114
    PubMedSearch in Google Scholar
  • 39 Oshima Y, Kadonosono K, Yamaji H et al. Japan Microincision Vitrectomy Surgery Study Group. Multicenter survey with a systematic overview of acute-onset endophthalmitis after transconjunctival microincision vitrectomy surgery. Am J Ophthalmol 2010; 150: 716-725
    CrossrefPubMedSearch in Google Scholar
  • 40 Eckardt C. Transconjunctival sutureless 23-gauge vitrectomy. Retina 2005; 25: 208-211
    CrossrefPubMedSearch in Google Scholar
  • 41 Sebag J. Pharmacologic vitreolysis. Retina 1998; 18: 1-3
    CrossrefPubMedSearch in Google Scholar
  • 42 Mojana F, Cheng L, Bartsch DU et al. The role of abnormal vitreomacular adhesion in age-related macular degeneration: spectral optical coherence tomography and surgical results. Am J Ophthalmol 2008; 146: 218-227
    CrossrefPubMedSearch in Google Scholar
  • 43 Sebag J. Pharmacologic vitreolysis – premise and promise of the first decade. Retina 2009; 29: 871-874
    CrossrefPubMedSearch in Google Scholar