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Eur J Pediatr Surg 2013; 23(04): 283-284
DOI: 10.1055/s-0032-1333115
Original Article
Georg Thieme Verlag KG Stuttgart · New York

C-Reactive Protein (CRP) Levels in Babies with Gastroschisis Managed with Preformed Silos

Ashok Daya Ram
1   Department of Paediatric Surgery, Birmingham Children's Hospital, Birmingham, United Kingdom
,
Melanie Drewett
2   Neonatal Unit, Princess Anne Hospital, Southampton, United Kingdom
,
David Burge
3   Department of Paediatric Surgery, Southampton University Hospital, Southampton, United Kingdom
› Author Affiliations
Further Information

Publication History

02 June 2012

17 October 2012

Publication Date:
25 March 2013 (online)

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Abstract

Background/Purpose The purpose of this study was to assess the degree of elevation of serum C-reactive protein (CRP) levels in infants with gastroschisis managed by placement of a preformed silo and subsequent nonoperative closure.

Methods CRP measurements were collected prospectively in infants with gastroschisis undergoing preformed silo placement until defect closure. Infants requiring operative closure or surgical silo placement were excluded as were any infants with confirmed sepsis during the closure period.

Results Data were available for 43 infants. Median CRP at birth was 8 mg/L (range 6 to 55) rising to 42 mg/L (range 35 to 68) at the time of closure.

Conclusions Elevation of serum CRP levels is to be expected in infants with gastroschisis managed with a preformed silo in the absence of infection. This data may be used to prevent unnecessary use of antibiotics in this group of patients.

Keywords

gastroschisis - C-reactive protein (CRP) - silo
 

  • References

  • 1 Banyard D, Ramones T, Phillips SE, Leys CM, Rauth T, Yang EY. Method to our madness: an 18-year retrospective analysis on gastroschisis closure. J Pediatr Surg 2010; 45 (3) 579-584
    CrossrefPubMedSearch in Google Scholar
  • 2 Owen A, Marven S, Johnson P , et al BAPS-CASS. Gastroschisis: a national cohort study to describe contemporary surgical strategies and outcomes. J Pediatr Surg 2010; 45 (9) 1808-1816
    CrossrefPubMedSearch in Google Scholar
  • 3 Benitz WE, Han MY, Madan A, Ramachandra P. Serial serum C-reactive protein levels in the diagnosis of neonatal infection. Pediatrics 1998; 102 (4) E41
    CrossrefPubMedSearch in Google Scholar
  • 4 Khalil BA, Baath ME, Baillie CT , et al. Infections in gastroschisis: organisms and factors. Pediatr Surg Int 2008; 24 (9) 1031-1035
    CrossrefPubMedSearch in Google Scholar
  • 5 Ramadan G, Rex D, Okoye B, Kennea NL. Early high C-reactive protein in infants with open abdominal wall defects does not predict sepsis or adverse outcome. Acta Paediatr 2010; 99 (1) 126-130
    PubMedSearch in Google Scholar