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J Reconstr Microsurg 2013; 29(03): 141-148
DOI: 10.1055/s-0032-1333314
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

FK506 and Nerve Regeneration: Past, Present, and Future

Petros Konofaos
1   Department of Plastic Surgery, University of Tennessee, Memphis, Tennessee, USA
,
Julia K. Terzis
2   Department of Plastic Surgery, New York University Medical Center and the International Institute of Reconstructive Microsurgery, Long Island City, New York, USA
› Author Affiliations
Further Information

Publication History

08 May 2012

05 October 2012

Publication Date:
15 January 2013 (online)

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Abstract

Promoting neurological recovery requires strategies that simultaneously provide protection to injured neurons and increase the numbers of neurons that extend axons while inducing more rapid and extensive axon regeneration across long nerve gaps. An agent that facilitates the speed and success of reinnervation will have direct applicability to the clinical management of severe peripheral nerve injuries. The immunosuppressive drug FK506 has been proven to have neuroprotective and neurotrophic actions in experimental models, increasing neurite elongation and accelerating the rate of nerve regeneration in vitro and in vivo. This review examines the role played by FK506, with primary focus on its role as a neurotrophic agent and its potential clinical use as a promoter of neurological recovery following peripheral nerve injuries.

Keywords

FK506 - peripheral nerve injuries - nerve regeneration - nerve gap
 

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