Download PDF
Semin Neurol 2012; 32(05): 528-530
DOI: 10.1055/s-0033-1334473
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Psychosis Related to Malaria Prophylaxis

Beverly J. Fauman
1   University of Michigan, Ann Arbor, Michigan
› Author Affiliations
Further Information

Publication History

Publication Date:
15 May 2013 (online)

    Permissions and Reprints

Corrected by:

Psychosis Related to Malaria ProphylaxisSemin Neurol 2013; 33(02): 167-168
DOI: 10.1055/s-0033-1351114

Abstract

Malaria is a worldwide health problem. Fortunately, there are treatments for the disease, and measures including antimalarials that significantly reduce the risk of acquiring malaria. Unfortunately, nearly all of the available preventatives have potential serious medical and psychiatric consequences, and should be considered as a cause of disturbed behavior in patients who have traveled to countries where malaria is prevalent.

Keywords

malaria - psychosis - antimalarials - malarone - chloroquine - primaquine - mefloquine - Larium
 

  • References

  • 1 Arguin PM, Mali S. Malaria, 2012 Yellow Book Travelers' Health. Atlanta, GA: Centers for Disease Control; 2012
    Google Scholar
  • 2 Murray CJL, Rosenfeld LC, Lim SS , et al. Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet 2012; 379 (9814) 413-431
    CrossrefPubMedGoogle Scholar
  • 3 Lidz T, Kahn RL. Toxicity of quinacrine (atabrine) for the central nervous system; an experimental study on human subjects. Arch Neurol Psychiatry 1946; 56: 284-299
    CrossrefPubMedGoogle Scholar
  • 4 Engel G, Romano J, Ferris EB. Effect of quinacrine (atabrine) on the central nervous system; clinical and electroencephalographic studies. Arch Neurol Psychiatry 1947; 58: 337-350
    CrossrefPubMedGoogle Scholar
  • 5 Mohan D, Mohandas E, Rajat R. Chloroquine psychosis: a chemical psychosis?. J Natl Med Assoc 1981; 73 (11) 1073-1076
    PubMedGoogle Scholar
  • 6 Good MI, Shader RI. Lethality and behavioral side effects of chloroquine. J Clin Psychopharmacol 1982; 2 (1) 40-47
    CrossrefPubMedGoogle Scholar
  • 7 Garg P, Mody P, Lall KB. Toxic psychosis due to chloroquine—not uncommon in children. Clin Pediatr (Phila) 1990; 29 (8) 448-450
    CrossrefPubMedGoogle Scholar
  • 8 Akhtar S, Mukherjee S. Chloroquine induced mania. Int J Psychiatry Med 1993; 23 (4) 349-356
    CrossrefPubMedGoogle Scholar
  • 9 Stuiver PC, Ligthelm RJ, Goud TJLM. Acute psychosis after mefloquine. Lancet 1989; 2 (8657) 282
    PubMedGoogle Scholar
  • 10 Stürchler D, Handschin J, Kaiser D , et al. Neuropsychiatric side effects of mefloquine. N Engl J Med 1990; 322 (24) 1752-1753
    PubMedGoogle Scholar
  • 11 Weinke T, Trautmann M, Held T , et al. Neuropsychiatric side effects after the use of mefloquine. Am J Trop Med Hyg 1991; 45 (1) 86-91
    PubMedGoogle Scholar
  • 12 Embrey E. Policy Memorandum on the Use of Mefloquine in Malaria Prophylaxis. Memorandum for assistant secretary of the Army, Navy, Air Force, Director of the Joint Staff. Washington, DC: U.S. Department of Defense; 2009
    Google Scholar
  • 13 Lydersen K. Lost to Lariam? Chicago Reader, Sept. 24, 2009. Available at: http://www.chicagoreader.com/chicago/lost-to-lariam/Content?oid=1201006
    Google Scholar
  • 14 Nosten F. Prophylactic effect of Malarone against malaria: all good news?. Lancet 2000; 356 (9245) 1864-1865
    CrossrefPubMedGoogle Scholar