Synthesis 2013; 45(11): 1475-1482
DOI: 10.1055/s-0033-1338437
paper
© Georg Thieme Verlag Stuttgart · New York

New Efficient Ligand-Free, Copper Nanoparticle Catalyzed Coupling Reactions of Aryl Halides with Diethyl Malonate to Produce α-Arylation of Malonates

Gita Pai
Department of Chemistry, University of Kalyani, Kalyani 741235, India   Fax: +91(33)25828282   Email: asoke@klyuniv.ac.in
,
Asoke P. Chattopadhyay*
Department of Chemistry, University of Kalyani, Kalyani 741235, India   Fax: +91(33)25828282   Email: asoke@klyuniv.ac.in
› Author Affiliations
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Publication History

Received: 15 January 2013

Accepted after revision: 02 April 2013

Publication Date:
29 April 2013 (online)


Abstract

Recently synthesized copper nanoparticles (Cu NP) were used to catalyze coupling of aryl halides with diethyl malonates to produce α-aryl malonates. Synthetic conditions, including solvents, relative amounts of reactants, catalyst, and temperature, etc. have been varied to obtain optimum conditions for such reactions using Cu NP. Unlike well-known cases, the present protocol developed here, with Cu NP, leads to synthesis of a wide variety of products under not very extreme conditions.

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