New Efficient Ligand-Free, Copper Nanoparticle Catalyzed Coupling Reactions of Aryl Halides with Diethyl Malonate to Produce α-Arylation of Malonates

Gita Pai; Asoke P. Chattopadhyay

doi:10.1055/s-0033-1338437

Synthesis, Table of Contents

Synthesis 2013; 45(11): 1475-1482
DOI: 10.1055/s-0033-1338437

paper

New Efficient Ligand-Free, Copper Nanoparticle Catalyzed Coupling Reactions of Aryl Halides with Diethyl Malonate to Produce α-Arylation of Malonates

Gita Pai

Department of Chemistry, University of Kalyani, Kalyani 741235, India Fax: +91(33)25828282 Email: asoke@klyuniv.ac.in

,

Asoke P. Chattopadhyay*

Department of Chemistry, University of Kalyani, Kalyani 741235, India Fax: +91(33)25828282 Email: asoke@klyuniv.ac.in

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Abstract

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Abstract

Recently synthesized copper nanoparticles (Cu NP) were used to catalyze coupling of aryl halides with diethyl malonates to produce α-aryl malonates. Synthetic conditions, including solvents, relative amounts of reactants, catalyst, and temperature, etc. have been varied to obtain optimum conditions for such reactions using Cu NP. Unlike well-known cases, the present protocol developed here, with Cu NP, leads to synthesis of a wide variety of products under not very extreme conditions.

Key words

copper nanoparticles - aryl halides - diethyl malonate - α-aryl malonates - Ullmann coupling

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References

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