Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor

Abstract

The application of meso-scale flow chemistry in research laboratories continues to increase. Here, we report on the use of a modular cryo-flow device as applied to a diastereoselective fluorination process. The reactor can be incorporated into existing flow chemistry setups to permit continuous processing at low temperatures without recourse to cryogenic consumables.

Key words

diastereoselective fluorination - flow chemistry - cryo-flow reactor - polymer-supported reagents - chiral auxiliary

• References and Notes

• 1 Now at Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.

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