Silver Acetate Mediated Acetoxylations of Alkyl Halides

Abstract

Silver acetate promotes the acetoxylation of alkyl halides under neutral reaction conditions. The reaction is applicable to primary and activated secondary alkyl halides, and 2,2-dibromoacetophenones for preparing the corresponding acetates in good yields. The presence of ester, amide, nitrile, hydroxy, and OTBDMS functions on the substrate is tolerated.

Key words

alkyl halides - substitution - acetoxylation - silver acetate - isomerization

• References

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