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Synthesis 2014; 46(06): 757-760
DOI: 10.1055/s-0033-1338585
paper
© Georg Thieme Verlag Stuttgart · New York

Iron(III) Chloride Catalyzed Formation of Aryl Hydrazides from Electron-Rich Arenes and Azodicarboxylates

Zhiyong Wang*
a   School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, P. R. of China   Fax: +86(23)65102531   eMail: zwang@cqu.edu.cn
,
Xiaoxiao Xing
a   School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, P. R. of China   Fax: +86(23)65102531   eMail: zwang@cqu.edu.cn
,
Lijun Xue
a   School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, P. R. of China   Fax: +86(23)65102531   eMail: zwang@cqu.edu.cn
,
Yan Xiong
a   School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, P. R. of China   Fax: +86(23)65102531   eMail: zwang@cqu.edu.cn
,
Ling Fang*
b   School of Environmental and Biological Engineering, Chongqing Technology and Business University, Chongqing 400067, P. R. of China
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Publikationsverlauf

Received: 30. Oktober 2013

Accepted after revision: 19. Dezember 2013

Publikationsdatum:
28. Januar 2014 (online)

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Abstract

Iron(III) chloride-catalyzed direct amination of electron-rich arenes with azodicarboxylates gives the corresponding aryl hydrazides in moderate to good yields within two minutes under mild conditions. This method will serve as an important tool for the synthesis of bioactive nitrogen-containing products and pharmaceuticals.

Key words

catalysis - iron - aminations - arenes - hydrazides

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    for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
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