RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000084.xml
Synthesis 2013; 45(13): 1853-1856
DOI: 10.1055/s-0033-1338878
DOI: 10.1055/s-0033-1338878
paper
Synthesis and Characterization of Ferrocene Acetals and Evaluation of Their Antineoplastic Properties by Using Breast Cancer Cell Lines In Vitro
Weitere Informationen
Publikationsverlauf
Received: 24. April 2013
Accepted: 08. Mai 2013
Publikationsdatum:
05. Juni 2013 (online)
To Dr. Scott E. Denmark in his 60th birthday’s celebration. With gratitude and best wishes from Dr. Mirna Rivera Claudio.
Abstract
Two new ferrocene acetals were synthesized from a chiral diol in toluene and characterized by a range of spectroscopic techniques. The biological activities of the products were evaluated by using the breast adenocarcinoma cell lines T47D, MCF7, ZR-75-1, MD-MB-468, and MD-MB-231. In comparison with tamoxifen, the ferrocene acetals showed moderate anticancer activity in vitro for the T47D and MCF7 cell lines.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
-
References
- 1 Current address: J. Santiago-Ofarril, Department of Pediatrics Research, The University of Texas MD Anderson Cancer Center, The University Graduate Biomedical Sciences at Houston, Houston TX, USA.
- 2a Ferrocenes: Homogeneous Catalysis, Organic Synthesis, Materials Science. Togni A, Hayashi T. Wiley-VCH; Weinhem: 1995
- 2b Jaouen G. Bioorganometallics . Wiley-VCH; Weinheim: 2005
- 2c Štěpnička P. Ferrocenes: Ligands, Materials and Biomolecules. Wiley; Chichester: 2008
- 2d Maree MD, Neuse EW, Erasmus E, Swarts JC. Metal-Based Drugs 2008; 217573
- 2e Shago RF, Swarts JC, Kreft E, Van Rensburg CE. J. Anticancer Res. 2007; 27: 3431
- 2f Chekhun VF, Kulik GI, Yurchenko OV, Tryndyak VP, Todor IN, Luniv LS, Tregubova NA, Pryzimirska TV, Montgomery B, Rusetskaya NV, Pogribny IP. Cancer Lett. 2006; 231: 87
- 2g Likhite VS, Stossi F, Kim K, Katzenellenbogen BS, Katzenellenbogen JA. Mol. Endocrinol. 2006; 20: 3120
- 2h Vessières A, Corbet C, Heldt JM, Lories N, Jouy N, Laïos I, Leclerq G, Jaouen G, Toillon RA. J. Inorg. Biochem. 2010; 104: 503
- 2i Michard Q, Jaouen G, Vessieres A, Bernard BA. J. Inorg. Biochem. 2008; 102: 1980
- 2j Bruijnincx PC. A, Sadler PJ. Curr. Opin. Chem. Biol. 2008; 12: 197
- 2k Wei CW, Peng Y, Zhang L, Huang Q, Cheng M, Liu YN, Li J. Bioorg. Med. Chem. Lett. 2011; 21: 5818
-
3 Riant O, Samuel O, Kagan HB. J. Am. Chem. Soc. 1993; 115: 5835
-
4 Hua DH, Lagneau NM, Chen Y, Robben PM, Clapham G, Robinson PD. J. Org. Chem. 1996; 61: 4508
- 5 Jiang Q, Zhong Q, Zhang Q, Zheng S, Wang G. ACS Med. Chem. Lett. 2012; 3: 392
- 6 Trivedi R, Deepthi SB, Giribabu L, Sridhar B, Sujitha P, Kumar CG, Ramakrishna KV. S. Eur. J. Inorg. Chem. 2012; 2267
- 7a National Cancer Institute. www.cancer.gov/cancertopics/ understandingcancer/estrogenreceptors (accessed May 2013).
-
7b Shiau AK, Barstad D, Loria PM, Cheng L, Kushner PJ, Agard DA. Cell 1998; 95: 927
- 7c Qadir MA, Kwok B, Dragowska WH, To KH, Le D, Bally MB, Gorski SM. Breast Cancer Res. Treat. 2008; 112: 389
- 8 Yamaguchi Y, Ding W, Sanderson CT, Borden ML, Morgan MJ, Kutal C. Coord. Chem. Rev. 2007; 251: 515
- 9 Mamane V, Ledoux-Rak I, Deveau S, Zyss J, Riant O. Synthesis 2003; 317